Histology Detective Case Resolution TemplateQuestion 1Breast cancer cells are identified in the sample of lung tissue.CharacteristicsThe cancer cells have the capability to create some sub-stances, tumor cell markers, which are discovered in the cytoplasm and on tumor cell membranes.Presence of bone morphogenetic proteins produced by breast cancer cells (Bunyaratavej 20).Has a malignant cell capability thus able to break away from the cancerous tumor to other locations. The malignant cell is characterized by invasive growth. genomic alterations. acceleration of the cell cycle. chemotaxis. increased cell mobility. alterations in the cellular surface. secretion of lytic factors (OCF Inc 1-2)Question 2It is evident that not all cancer cells have the capabilities to survive the passage to a new area of the body (metastasis). Many morphological cancer cells die since they are not prepared for the whole process of metastasis. Characteristics in the tumor cells, such as aggregation, deformability, and presence of adhesive molecules, avert cancer tumor cells from persevering disintegration from the tumor (Baba 54). The body also has prevention and fighting agents, such as platelets blood turbulence, T cells, macrophages, and natural killer cells that kill moving cancer cells. However, majority of breast cancer cells are able to pass and endure the condition to destination (maybe due to short distance).I compared morphological distinctiveness, ploidy, and immunohistochemical display of estrogen receptors, HER2/neu and p53 proteins and progesterone receptors present in these cells (Baba 42). Question 3Outside sources:Baba, Alecsandru I, and Cornel Cătoi. Comparative Oncology. Chapter 3: Tumor Cell morphology. Accessed from http://www.ncbi.nlm.nih.gov/books/NBK9553/OCF Inc. Metastasis, 2013. Accessed from http://www.oralcancerfoundation.org/facts/metastasis.htmQuestion 4These items provide evidence based proofs that are essential in understanding the case study.Question 5 Other findings include morphological and functional characteristics of the malignant cell that associate with metastasis. Morphologically, the tumor cell is characterized by a big nucleus, having an uneven shape and size, the nucleoli are vast, and the cytoplasm is inadequate and intensely tinted or pale (Baba 54).Question 6It is hard to differentiate cells that have morphological features from other cells since metastasis refers to capability of a cell to overcome body resistant agents. Question 7 The cells are breast cancer oriented and treatment should be tied source, not destination. The lung cancer identified is a product of breast cancer cells metastasis and the solution should be source oriented. Expected observations are that the patient has earlier been diagnosed with breast cancer and treatment was not successful, or he/she is suffering from breast cancer too (OCF Inc 1-2).Question 8The solution is to assess cancer history of the patient and make proper breast cancer diagnosis and assessment prior to treatment. Confident rate is 4/5.Question 9Study of breast cancer cells properties and knowledge of cancer cells such as primary and secondary cancer formed the basis of my assessment and conclusion. Implementation of different strategies and resources such as breast cancer diagnosis first then proceeding to lung cells testing would be applicable. Works CitedBaba, Alecsandru I, and Cornel Cătoi. Comparative Oncology. Bucharest: The Publishing House of the Romanian Academy, 2007. Print. Chapter 3: Tumor Cell morphology. Accessed from http://www.ncbi.nlm.nih.gov/books/NBK9553/OCF Inc. Metastasis, 2013. Accessed from http://www.oralcancerfoundation.org/facts/metastasis.htmBunyaratavej, Pintippa. Bone Morphogenetic Proteins Secreted by Breast Cancer Cells Upregulate Bone Sialoprotein Expression in Preosteoblast Cells: A Thesis Submitted in Partial Fulfillment … for the Degree of Master of Science. , 2000. Print.
Histology Detective Resolution Template